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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia

Fig. 3

EWCE analysis on differentially expressed proteins shows cell type specific involvement in genetic FTD subtypes. A EWCE analysis of lower (n = 331) and higher (n = 248) expressed proteins in frontal cortical FTD-GRN vs NDC. C EWCE analysis of lower (n = 246) and higher (n = 242) expressed proteins in temporal cortical FTD-MAPT vs NDC. EWCE analysis is performed using bootstrapped t-test statistics with a multiple testing correction done by the Benjamini–Hochberg method. Comparison of EWCE analysis results between FTD-GRN and FTD-MAPT shows astrocyte (both p = 0) and endothelial cell (p = 0 and p = 0.0133, respectively) enrichment for higher expressed proteins, and excitatory (both p = 0) and inhibitory (p = 0 and p = 0.0264) neuronal cell type enrichment for lower expressed proteins in both FTD subtypes. In FTD-MAPT, distinct oligodendrocyte enrichment (p = 0.0004) is observed for lower expressed proteins. (B,D) Proteins that are highly enriched for specific cell types (see methods) show the extent of differential protein expression ongoing in these cell types. In these plots, cell type specificity values for excitatory and inhibitory neurons are summed per protein. Exc.; excitatory, Inh.; Inhibitory, s.d.; standard deviation

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