Fig. 8
From: Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome
Images of the FC showing APP/Aβ-ir deposits in gray and white matter in NTD at 28 and 174 wk (A–D) and in DS 31 and 196 wk cases (E–H). Insets C and G show APP/Aβ-ir pyramidal neurons in 174 wk NTD (C) and 196 wk DS (G). I–L. Tissue in panels A to H were counterstained with hematoxylin. Images showing CP13 immunostaining in NTD at 38 and 41 wk and in DS at 33 and 196 wk. Granular CP13 immunoreactivity was observed in layer I in 41 wk NTD (J) and 33 wk DS (K) cases, but no CP13-ir cells were detected (I–L). M–N. Boxplots showing no significant differences in plaque load (M) and plaque counts (N) between NTD (n = 9) and DS (n = 10) groups (Mann–Whitney rank sum test). Abbreviation: wm, white matter. Scale bars: A–L = 50 µm, L applies to I–K, insets in C and G = 10 µm