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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome

Fig. 1

Low-magnification images of thionin-stained FC showing lamination patterns in 28 (A), 44 (C), and 174 (E) wk in NTD and 32 (B), 44 (D), and 196 (F) wk in DS. Layers I-VI were also imaged at a higher magnification for each NTD (28 wk: a1a5; 44 wk: c1c5; 174 wk: e1e5) and DS (32 wk: b1b5; 44 wk: d1d5; 196 wk: f1f5) case showing cell type and cellular distribution. Note the presence of pyramidal neurons in layer V at 28 wk in a premature NTD infant, while lacking in a 32 wk DS infant, as well the higher cell density in layers II to VI in DS than in NTD at all ages. Scale bar in B, D and F = 200 µm and applies to A, C and E; a5, d4 and f4 = 25 µm applies to a1b2, c1d3 and e1f3, respectively

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