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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: The polyG diseases: a new disease entity

Fig. 1

Typical brain radiological and pathological features in patient with NOTCH2NLC-CGG expansion. A and B Representative brain DWI image and T2-weighted image of patients with NOTCH2NLC-related polyG disease. C Representative H&E staining image show eosinophilic NIIs (black arrow) in sweat gland cells of skin D Representative immunostaining image show p62-positive NIIs (black arrow) in skin. E Representative electron microscopy image revealed Intranuclear tubulofilamentous inclusions in the skin of NIID patient. F Immunofluorescence against uN2CpolyG using 4D12 antibody (red, generously providing by Dr. Nicolas Charlet-Berguerand) and p62 antibody (green) on brain section from patient with NOTCH2NLC-CGG repeat expansion. Nuclei were counterstained with DAPI

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Acta Neuropathologica Communications

ISSN: 2051-5960

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