Fig. 4

Protein levels for total, 119CTT, 122CTT, and pSer129 aSyn in different fractions of brain tissue extracts of donors with a synucleinopathy and controls. Protein levels are expressed as µg/g wet tissue. Levels of the studied forms of aSyn in brain tissue derived from donors with a synucleinopathy (including PD, PDD, DLB and MSA patients; dark bars) and controls (light bars), in detergent-soluble and –insoluble fractions. Donors with PSP and AD were excluded from the analysis. Statistical comparison between donors with synucleinopathies and controls subjects was done using Mann–Whitney U tests. *p < 0.05; **p < 0.01; ***p < 0.001. Bar graphs indicate mean ± standard deviation