Fig. 2

RPA immunoreactivity patterns towards fractionated brain extracts suggest disease-related biochemical aSyn manifestations in different neurological disorders. Heat maps of log10-transformed p-values of group comparisons in detergent-soluble and -insoluble fractions after Dunnett’s post-hoc correction. Colors indicate the significance level for each diagnostic group compared to neurologically normal subjects (controls), with orange indicating higher RPA immunoreactivities, cyan values indicating lower RPA immunoreactivities, while black indicates no difference (see also color key). Heat maps were generated by unsupervised hierarchical clustering. On top of each heat map, the clustering of antibody reactivities according to their epitopes is shown. HIP, hippocampus; PUT, putamen; SN, substantia nigra. Note: SN from AD was not extracted