Fig. 3

Genetic deletion of CK2α’ improved motor coordination in zQ175. A–C, Latency to fall off the rod (Rotarod test) for three consecutive days. D–F, Number of foot slips recorded while walking on four different types of beams with different degrees of difficulty from less to more challenging: medium-square, medium round, small-square and small-round (Beam test). Analyses were performed at 3, 6 and 12 months of age (n = 16–18 mice/genotype in 3 months, n = 12–14 for 6 months and n = 5–6 for 12 months). Error bars denote mean ± SEM, values were analyzed by two-way ANOVA with Sidak’s post-hoc test. p-values < 0.05 are indicated, n.s = not significant