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Table 2 Comparing variables depending on driver gene mutation, tumor location, and subgroups

From: Clinical significance of NF2 alteration in grade I meningiomas revisited; prognostic impact integrated with extent of resection, tumour location, and Ki-67 index

Variables

 

Non-recur

Recur

p

NF2

Non–NF2

p

Supratent

Infratent

p

Sup. NF2

Inf. NF2

Sup. nNF2

Inf. nNF2

p

In all tumor

N = 281

N = 236

N = 45

 

N = 150

N = 131

 

N = 188

N = 93

 

N = 109

N = 44

N = 79

N = 49

 

5-yr PFS

83.4%

 

77.9%

90.3%

0.04

82.1%

86.7%

0.18

72.8%

94.1%

95.3%

80.6%

6.2 × 10–4

GTR

236 (84.0%)

209 (88.6%)

27 (60.0%)

1.5 × 10–5

132 (88.0%)

104 (79.3%)

0.19

158 (84.0%)

78 (83.9%)

1.0

91 (83.5%)

41 (93.2%)

67 (84.8%)

37 (75.5%)

0.04

NF2

152 (54.1%)

121 (51.3%)

31 (68.9%)

0.03

 

109 (58.0%)

43 (46.2%)

0.07

 

Supratent

188 (66.9%)

152 (64.4%)

36 (80.0%)

0.05

109 (72.7%)

79 (60.3%)

0.07

  

Ki-67 index

2.5 ± 2.0

2.2 ± 1.6

3.7 ± 3.2

0.01

2.9 ± 2.4

2.0 ± 1.4

0.004

2.7 ± 2.3

2.0 ± 1.3

0.02

3.2 ± 2.6

2.2 ± 1.4

2.0 ± 1.5

1.8 ± 1.2

8.4 × 10–5

In GTR

N = 236

N = 209

N = 27

 

N = 131

N = 105

 

N = 158

N = 78

 

N = 90

N = 42

N = 68

N = 36

 

5-yr PFS

86.9%

 

81.5%

94.1%

0.02

84.4%

93.1%

0.01

77.3%

93.8%

94.4%

92.3%

6.2 × 10–3

NF2

131 (55.5%)

110 (52.6%)

21 (77.8%)

0.01

 

90 (57.0%)

41 (52.6%)

0.57

 

Supratent

158 (66.9%)

133 (63.6%)

25 (92.6%)

0.001

90 (68.7%)

68 (64.8%)

0.57

  

Ki-67 index

2.5 ± 2.0

2.3 ± 1.6

4.3 ± 3.4

0.002

2.8 ± 2.3

2.1 ± 1.4

0.008

2.7 ± 2.3

2.0 ± 1.2

0.03

3.2 ± 2.6

2.1 ± 1.3

2.2 ± 1.6

1.8 ± 1.2

0.01

In STR

N = 45

N = 27

N = 18

 

N = 20

N = 25

 

N = 30

N = 15

 

N = 18

N = 2

N = 12

N = 13

 

5-yr PFS

65.4%

 

55.6%

75.1%

0.21

69.3%

58.2%

0.61

50.0%

100%

100%

51.3%

0.05

NF2

20 (44.4%)

10 (37.0%)

10 (55.6%)

0.2

 

18 (60.0%)

2 (13.3%)

0.004

 

Supratent

30 (66.7%)

19 (70.4%)

11 (61.1%)

0.53

18 (90.0%)

12 (48.0%)

0.004

  

Ki-67 index

2.3 ± 2.1

1.9 ± 1.7

2.8 ± 2.7

0.42

3.3 ± 2.6

1.5 ± 1.2

0.01

2.4 ± 2.3

2.0 ± 1.7

0.6

3.3 ± 2.6

3.5 ± 3.5

1.2 ± 0.9

1.7 ± 1.4

0.1

  1. Recur.: Recurrence, NF2 meningioma: meningioma with presence of NF2 variant or 22q loss, Supratent.: Supratentorial, Infratent.: Infratentorial, Sup. NF2: Supratentorial NF2, Inf. NF2: Infratentorial NF2, Sup. nNF2: Supratentorial non–NF2, Inf. nNF2: Infratentorial non–NF2, 5-yr PFS: 5-year progression free survival, GTR: gross total resection, STR:subtotal resection