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Table 1 List of GPI-anchored proteins with q < 0.1 that are differential between CSF from Control individuals and ALS patients. N, neurons; O, oligodendroglial lineage; A, astrocytes; E, endothelial cells; MG, microglia. Cell specific expression profiles were derived from searches of brainrnaseq.org and proteinatlas.org

From: The distribution and function of GDE2, a regulator of spinal motor neuron survival, are disrupted in Amyotrophic Lateral Sclerosis

Protein name

Gene symbol

P value

q-value

Z-score (ALS/control)

Cell Type

Acetylcholinesterase

ACHE

0.0040

0.0535

− 0.451

N, O

Thy-1 membrane glycoprotein (Fragment)

THY1

0.0037

0.0537

− 0.533

N, O, E

Semaphorin-7A

SEMA7A

0.0030

0.0573

− 0.674

N, O, MG

Repulsive guidance molecule A

RGMA

0.0088

0.0576

− 0.547

N, A

Netrin-G1

NTNG1

0.0033

0.0580

− 0.566

N, O

Carbonic anhydrase 4

CA4

0.0069

0.0596

− 0.532

N, MG, E

RGM domain family member B

RGMB

0.0046

0.0597

− 0.569

N, O, A, E

Neuronal growth regulator 1

NEGR1

0.0023

0.0605

− 0.565

N, O, A, E

Ephrin-A3

EFNA3

0.0149

0.0618

− 0.571

N

Reticulon-4 receptor (Fragment)

RTN4R

0.0089

0.0625

− 0.593

N, A

Limbic system-associated membrane protein (Fragment)

LSAMP

0.0103

0.0715

− 0.390

N, O, A

Contactin-1

CNTN1

0.0014

0.0735

− 0.337

N, O, A

Cadherin-13

CDH13

0.0317

0.0736

− 0.569

N, O

Oligodendrocyte-myelin glycoprotein

OMG

0.0021

0.0750

− 0.663

N, O, A

Contactin-4

CNTN4

0.0064

0.0760

− 0.401

N, O

Low affinity immunoglobulin gamma Fc region receptor III-B

FCGR3B

0.0514

0.0771

− 0.922

MG

Ciliary neurotrophic factor receptor subunit alpha

CNTFR

0.0082

0.0773

− 0.377

A

Reticulon-4 receptor-like 1

RTN4RL1

0.0245

0.0816

− 0.509

N

Brevican core protein

BCAN

0.0178

0.0845

− 0.460

A, O

Reticulon-4 receptor-like 2

RTN4RL2

0.0006

0.0860

− 0.677

N, O

Opioid-binding protein/cell adhesion molecule

OPCML

0.0278

0.0877

− 0.419

N, O, E

Glypican-1

GPC1

0.0151

0.0904

− 0.355

N, A

Neuritin

NRN1

0.0419

0.0923

− 0.465

N, O, E

Contactin-3

CNTN3

0.0197

0.0941

− 0.379

N, O

Ephrin-A5

EFNA5

0.0459

0.0967

− 0.463

N, A

GDNF family receptor alpha-2

GFRA2

0.0432

0.0969

− 0.527

N

GPI-anchored high density lipoprotein-binding protein 1

GPIHBP1

0.0905

0.0974

− 0.996

O, E

Contactin-6

CNTN6

0.0317

0.0981

− 0.376

N, O

Neural cell adhesion molecule 1

NCAM1

0.0160

0.0991

− 0.319

N, O, A