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Table 5 Predictors of percentage glial area in the immediate A\(\upbeta\) plaque microenvironment

From: Frontal lobe microglia, neurodegenerative protein accumulation, and cognitive function in people with HIV

 

APOE \(\upvarepsilon\)4 positive

APOE \(\upvarepsilon\)4 negative

p

Male sex

Female sex

p

Multivariate analysis

 

n = 16

n = 15

 

n = 15

n = 16

 

adjusted r2, p

predictor F ratio, p

Cored plaques

GFAP plaque

1.1153 [0.2096,1.4996]

0.6259 [0.0216,1.0250]

0.0770

1.0167 [0.0434,1.3705]

0.6481 [0.1276,1.1448]

0.7288

no significant models

 

GFAP rim

0.8644 [0.1481,1.2017]

0.0885 [0.0128,0.6391]

0.0162

0.4805 [0.0457,1.2213]

0.4148 [0.0736,0.7320]

0.5254

adj r2 = 0.1748 p = 0.0241

APOE \(\upvarepsilon\)4 F = 5.8712 p = 0.0241

CD68 plaque

0.8004 [0.1787,1.1041]

0.5310 [0.1028,0.9554]

0.4009

0.7098 [0.1445,1.0485]

0.7086 [0.1428,1.0210]

0.9081

no significant models

 

CD68 rim

0.1313 [0.0709,0.2012]

0.1620 [0.0615,0.1708]

0.9307

0.1632 [0.0642,0.2460]

0.1416 [0.0689,0.1706]

0.6439

no significant models

 

Iba1 plaque

1.0879 (0.1029)

0.7711 (0.1119)

0.0049

1.0833 (0.1093)

0.8021 (0.1093)

0.0824

adj r2 = 0.1270 p = 0.0489

APOE \(\upvarepsilon\)4 F = 4.3449 p = 0.0489

Iba1 rim

0.6145 (0.0680)

0.4982 (0.0739)

0.2595

0.6496 (0.0679)

0.4728 (0.0679)

0.0790

adj r2 = 0.1950 p = 0.0395

sex F = 6.4975 p = 0.0187 group (HIV-D) F = 3.7534 p = 0.0663

diffuse plaques

GFAP plaque

0.6471 [0.2113,1.0093]

0.0592 [0.0382,0.6198]

0.0057

0.6681 [0.0948,1.0842]

0.1733 [0.0485,0.6322]

0.0820

adj r2 = 0.3369 p = 0.0049

APOE \(\upvarepsilon\)4 F = 8.1618 p = 0.0083 sex F = 7.3948 p = 0.0115 group (HIV-D) F = 3.2991 p = 0.0529

GFAP rim

0.5597 [0.1759,0.8201]

0.1045 [0.0492,0.4170]

0.0143

0.4459 [0.0558,0.8549]

0.2105 [0.0573,0.5591]

0.1331

adj r2 = 0.3074 p = 0.0047

APOE \(\upvarepsilon\)4 F = 5.7802 p = 0.0233 sex F = 6.3260 p = 0.0182 group (HIV-U) F = 3.9262 p = 0.0578

CD68 plaque

0.3024 [0.1512,0.3865]

0.1065 [0.0358,0.1749]

0.0072

0.1749 [0.1065,0.2993]

0.1555 [0.0778,0.3772]

0.8433

adj r2 = 0.1081 p = 0.0397

APOE \(\upvarepsilon\)4 F = 4.6366 p = 0.0397

CD68 rim

0.1565 [0.1110,0.2460]

0.1356 [0.1028,0.1605]

0.1989

0.1504 [0.1086,0.1667]

0.1442 [0.1110,0.2108]

0.9527

no significant models

 

Iba1 plaque

0.8684 (0.0800)

0.6428 (0.0826)

0.0595

0.9031 (0.0797)

0.6244 (0.0772)

0.0178

adj r2 = 0.1504 p = 0.0178

sex F = 6.3117 p = 0.0178

Iba1 rim

0.6526 (0.0623)

0.5377 (0.0643)

0.2095

0.6865 (0.0620)

0.5131 (0.0600)

0.0537

adj r2 = 0.0921 p = 0.0537

sex F = 4.0449 p = 0.0537

  1. All percentage glial areas log transformed prior to analysis; median and IQR for measures of CD68 and GFAP, mean and SEM for measures of Iba1. GFAP: glial fibrillary acidic protein; adj r2 = adjusted r2; plaque measurements taken within region of A\(\upbeta\) deposition; rim measurements obtained within 50 um radius from the plaque border. Multivariable models included HIV group status as a potential predictor (bivariate analysis for this predictor is displayed in supplemental Table 1)
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Acta Neuropathologica Communications

ISSN: 2051-5960

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