Frontal lobe microglia, neurodegenerative protein accumulation, and cognitive function in people with HIV

Table 2 Frontal lobe microglial cell percentage areas in HIV-negative and HIV-positive individuals with and without control of plasma viremia

	Total sample n = 254	HIV-neg n = 63	HIV-U n = 91	HIV-D n = 100	p
CD68 cortex^a	0.0953 [0.0509,0.1646]	0.0699 [0.0361,0.1146	0.0820 [0.0490,0.1275]	0.1200 [0.0748,0.2176]	< 0.0001
CD163 cortex^b	0.0442 [0.0261,0.0767]	0.0484 [0.0266,0.0762]	0.0348 [0.0202,0.0670]	0.0537 [0.02768,0.0919]	0.0551
Iba1 cortex^a	1.1979 [0.6588,1.9662]	1.0879 [0.6085,1.6644]	1.1252 [0.6600,1.8503]	1.5518 [0.6813,2.3906]	0.0154
CD68 WM^a	0.2739 [0.1562,0.4391]	0.1967 [0.1261,0.3117]	0.2619 [0.1450,0.3748]	0.3709 [0.2230,0.6377]	< 0.0001
CD163 WM^a	0.0500 [0.0306,0.0897]	0.0459 [0.0292,0.0687]	0.0463 [0.0267,0.0817]	0.0655 [0.0342,0.1160]	0.0097
Iba1 WM^a	1.8098 [0.9741,2.5976]	1.5831 [0.8477,2.3285]	1.6913 [0.7707,2.4884]	2.0447 [1.2424,2.9518]	0.0214

HIV-neg: HIV negative; HIV-U: HIV undetectable; HIV-D: HIV detectable; WM: subcortical white matter; A\(\upbeta\): Amyloid beta
Median and inter quartile range displayed for all markers
P values refer to comparisons between HIV-neg, HIV-U, and HIV-D groups by Kruskal–Wallis tests
^aHIV-D > HIV-U, HIV-neg ^bHIV-D > HIV-U

ISSN: 2051-5960