Table 2 Statistical Analyses
Figure | Comparison | Type of test | Statistic | p values and 95% CI |
|---|---|---|---|---|
3B | 3 mo. stereology interaction | Two-Way ANOVA | F(1,36) = 0.6118 | p = 0.4392 |
3 mo. stereology hemisphere | Two-Way ANOVA | F(1,36) = 3.908 | p = 0.0557 | |
3 mo. stereology treatment | Two-Way ANOVA | F(1,36) = 6.667 | p = 0.0140 | |
3 mo. Monomer v PFF: Contra | Sidak’s multiple comparisons | 95% CI: -619.3 to 2015 p = 0.3779 | ||
3 mo. Monomer v PFF: Ipsi | Sidak’s multiple comparisons | 95% CI: 26.42 to 2751 p = 0.0451 | ||
3 mo. Contra vs Ipsi: Monomer | Sidak’s multiple comparisons | 95% CI: -799.1 to 1785 p = 0.6145 | ||
3 mo. Contra vs Ipsi: PFF | Sidak’s multiple comparisons | 95% CI: -289.8 to 2568 p = 0.1370 | ||
3C | 3 mo.: % uninjected | Unpaired two-tailed t-test | t = 1.808, df = 18 | P = 0.0874 |
3E | 6 mo. stereology interaction | Two-Way ANOVA | F(1,42) = 2.311 | p = 0.1359 |
6 mo. stereology hemisphere | Two-Way ANOVA | F(1,42) = 6.765 | p = 0.0128 | |
6 mo. stereology treatment | Two-Way ANOVA | F(1,42) = 2.692 | p = 0.1083 | |
6 mo. Monomer v PFF: Contra | Sidak’s multiple comparisons | 95% CI: -724.8 to 780.1 P = 0.9954 | ||
6 mo. Monomer v PFF: Ipsi | Sidak’s multiple comparisons | 95% CI: -27.25 to 1478 P = 0.0606 | ||
6 mo. Contra vs Ipsi: Monomer | Sidak’s multiple comparisons | 95% CI: -488.0 to 938.8 P = 0.6853 | ||
6 mo. Contra vs Ipsi: PFF | Sidak’s multiple comparisons | 95% CI: 176.8 to 1714 P = 0.0134 | ||
3F | 6 mo.: % uninjected | Unpaired two-tailed t-test | t = 2.286, df = 21 | P = 0.0328 |
4B | 3 mo. VDAC1 Interaction | Two-way ANOVA | F(1,28) = 2.969 | p = 0.0959 |
3 mo. VDAC1 Hemisphere | Two-way ANOVA | F(1,28)= 2.969 | p = 0.0959 | |
3 mo. VDAC1 Treatment | Two-way ANOVA | F(1,28) = 6.355 | p = 0.0177 | |
3 mo. VDAC1, Ipsi vs Contra: PFF | Sidak’s multiple comparisons | 95% CI: -1.045 to -0.01615 p = 0.0424 | ||
3 mo. VDAC1, Monomer v PFF: Contra | Sidak’s multiple comparisons | 95% CI: -1.168 to -0.1390 p = 0.0112 | ||
4C | 3 mo. COX-IV Interaction | Two-way ANOVA | F(1,28) = 0.1284 | p = 0.7227 |
3 mo. COX-IV Hemisphere | Two-way ANOVA | F(1,28) = 0.1284 | p = 0.7227 | |
3 mo. COX-IV Treatment | Two-way ANOVA | F(1,28) = 7.425 | p = 0.0110 | |
3 mo. COX-IV, Monomer v PFF: Ipsi | Sidak’s multiple comparisons | 95% CI: -2.925 to 0.1175 p = 0.0742 | ||
3 mo. COX-IV, Monomer v PFF: Contra | Sidak’s multiple comparisons | 95% CI: -2.599 to 0.4438 p = 0.1997 | ||
4D | 3 mo. Tomm-20 Interaction | Two-way ANOVA | F(1,28) = 0.4529 | p = 0.5065 |
3 mo. Tomm-20 Hemisphere | Two-way ANOVA | F(1,28) = 0.4529 | p = 0.5065 | |
3 mo. Tomm-20 Treatment | Two-way ANOVA | F(1,28)= = 4.356e-0.005 | p = 0.9948 | |
4E | 3 mo. Ndusf4 Interaction | Two-way ANOVA | F(1,28) = 0.03257 | p = 0.8581 |
3 mo. Ndusf4 Hemisphere | Two-way ANOVA | F(1,28) = 0.03257 | p = 0.8581 | |
3 mo. Ndusf4 Treatment | Two-way ANOVA | F(1,28) = 0.01352 | p = 0.9083 | |
4G | 6 mo. VDAC1 Interaction | Two-way ANOVA | F(1, 32) = 2.126 | p = 0.1546 |
6 mo. VDAC1 Hemisphere | Two-way ANOVA | F(1,32) = 2.126 | p = 0.1546 | |
6 mo. VDAC1 Treatment | Two-way ANOVA | F(1,32) = 0.1131 | p = 0.7388 | |
6 mo. VDAC1, Ipsi vs Contra: PFF | Sidak’s multiple comparisons | 95% CI: -0.06415 to 0.9943 p = 0.0926 | ||
4H | 6 mo. COX-IV Interaction | Two-way ANOVA | F(1,32) = 3.299 | p = 0.0787 |
6 mo. COX-IV Hemisphere | Two-way ANOVA | F(1,32) = 3.299 | p = 0.0787 | |
6 mo. COX-IV Treatment | Two-way ANOVA | F(1,32) = 0.3907 | p = 0.5364 | |
6 mo. COX-IV, Ipsi vs Contra: PFF | Sidak’s multiple comparison | 95% CI: 0.04751 to 1.051 p = 0.0299 | ||
6 mo. COX-IV, Monomer v PFF: Ipsi | Sidak’s multiple comparison | 95% CI: -0.8706 to 0.1326 P = 0.1791 | ||
4I | 6 mo. Tomm-20 Interaction | Two-way ANOVA | F(1,32) = 0.06019 | p = 0.8078 |
6 mo. Tomm-20 Hemisphere | Two-way ANOVA | F(1,32) = 0.06019 | p = 0.8078 | |
6 mo. Tomm-20 Treatment | Two-way ANOVA | F(1,32) = 0.3443 | p = 0.5615 | |
4 J | 6 mo. Ndusf4 Interaction | Two-way ANOVA | F(1,28) = 0.02204 | p = 0.8830 |
6 mo. Ndusf4 Hemisphere | Two-way ANOVA | F(1,28) = 0.02204 | p = 0.8830 | |
6 mo. Ndusf4 Treatment | Two-way ANOVA | F(1,28) = 0.01168 | p = 0.9147 | |
5B | 3 mo. DRP1 Interaction | Two-way ANOVA | F(1,28) = 0.2058 | p = 0.6536 |
3 mo. DRP1 Hemisphere | Two-way ANOVA | F(1,28) = 0.2058 | p = 0.6536 | |
3 mo. DRP1 Treatment | Two-way ANOVA | F(1,28) = 7.005 | p = 0.0132 | |
3 mo. DRP1, Monomer vs PFF: Ipsi | Sidak’s multiple comparison | 95% CI:-0.01347 to 0.3597 p = 0.0723 | ||
5C | 3 mo. OPA1 Interaction | Two-way ANOVA | F(1,28) = 0.05688 | p = 0.8132 |
3 mo. OPA1 Hemisphere | Two-way ANOVA | F(1,28) = 0.05688 | p = 0.8132 | |
3 mo. OPA1 Treatment | Two-way ANOVA | F(1,28) = 2.698 | p = 0.1116 | |
5D | 3 mo. FIS1 Interaction | Two-way ANOVA | F(1,28) = 0.003612 | p = 0.9525 |
3 mo. FIS1 Hemisphere | Two-way ANOVA | F(1,28) = 0.003612 | p = 0.9525 | |
3 mo. FIS1 Treatment | Two-way ANOVA | F(1,28) = 0.06165 | p = 0.8057 | |
5E | 3 mo. MIRO Interaction | Two-way ANOVA | F(1,28) = 0.3095 | p = 0.5824 |
3 mo. MIRO Hemisphere | Two-way ANOVA | F(1,28) = 0.3095 | p = 0.5824 | |
3 mo. MIRO Treatment | Two-way ANOVA | F(1,28) = 0.009319 | p = 0.9238 | |
5G | 6 mo. DRP1 Interaction | Two-way ANOVA | F(1,32) = 0.2508 | p = 0.6199 |
6 mo. DRP1 Hemisphere | Two-way ANOVA | F(1,32) = 0.2508 | P = 0.6199 | |
6 mo. DRP1 Treatment | Two-way ANOVA | F(1,32) = 0.5342 | p = 0.4702 | |
5H | 6 mo. OPA1 Interaction | Two-way ANOVA | F(1,32) = 0.06358 | p = 0.8025 |
6 mo. OPA1 Hemisphere | Two-way ANOVA | F(1,32) = 0.06358 | p = 0.8025 | |
6 mo. OPA1 Treatment | Two-way ANOVA | F(1,32) = 0.2102 | p = 0.6497 | |
5I | 6 mo. FIS1 Interaction | Two-way ANOVA | F(1,32) = 0.1527 | P = 0.6985 |
6 mo. FIS1 Hemisphere | Two-way ANOVA | F(1,32) = 0.1527 | P = 0.6985 | |
6 mo. FIS1 Treatment | Two-way ANOVA | F(1,32) = 1.472 | P = 0.2339 | |
5 J | 6 mo. MIRO Interaction | Two-way ANOVA | F(1,32) = 0.01677 | p = 0.8978 |
6 mo. MIRO Hemisphere | Two-way ANOVA | F(1,32) = 0.01677 | p = 0.8978 | |
6 mo. MIRO Treatment | Two-way ANOVA | F(1,32) = 0.1738 | p = 0.6795 |