Fig. 7

Altered striatal mitochondrial respiratory chain complex activity in PFF-injected mice. Activity of mitochondrial respiratory chain complex I and complex IV, as well as citrate synthase activity, measured at 3 months p.i. (A–C) and 6 months p.i. (D, E). No significant differences were found at 3 months p.i. (A–C). D At 6 months p.i., complex I activity was significantly increased in the contralateral hemisphere of PFF-injected animals compared to monomer (Two-way ANOVA, main effect of PFF, F _(1,32) = 14.72, p = 0.0006; Monomer vs PFF: contralateral, Sidak’s multiple comparison’s test, p = 0.0018, N = 9 monomer, 9 PFF). E, F There were no significant differences in complex IV or citrate synthase activity at 6 months p.i