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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Analysis of hemisphere-dependent effects of unilateral intrastriatal injection of α-synuclein pre-formed fibrils on mitochondrial protein levels, dynamics, and function

Fig. 5

Effect of PFF-seeded pathology on cortical levels of proteins involved in mitochondrial dynamics. A Representative western blot images of mitochondrial fusion and fission proteins DRP1, OPA1, FIS1, and MIRO1 in monomer- and PFF-injected mice 3 months p.i. B Main effect of PFF injection is observed in DRP1 levels (Two-way ANOVA, F(1,28) = 7.005, p = 0.0132, N = 8 monomer, 8 PFF). No changes were detected in levels of OPA1 (C), FIS1 (D), or MIRO1 (E). F Representative western blot images of mitochondrial fusion and fission proteins DRP1, OPA1, FIS1, and MIRO1 in monomer- and PFF-injected mice 6 months p.i. G–J No changes in were detected in cortical levels of mitochondrial proteins in monomer or PFF-injected mice 6 months p.i. (N = 9 monomer, 9 PFF). GAPDH was used as a loading/normalization control

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Acta Neuropathologica Communications

ISSN: 2051-5960

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