Fig. 2

A Volcano plots showing differentially expressed genes identified between TCGA CIC mutation groups within Type I LGG. B Comparison of expression between differentially expressed genes identified in CIC LOF and CIC missense Type I LGGs C Heatmap of gene set enrichment analysis comparison between CIC LOF and CIC missense Type I LGG D) Gene set enrichment analysis for up (top) and down (bottom) regulated differentially expressed genes shared between CIC LOF and CIC missense Type I LGG. * Gene sets in red related to MAPK/RTK and blue related to neuronal/development/differentiation