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Table 1 Baseline demographic and neuropathological features of the total N = 55 subjects included

From: Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages

Cognitive status

Control

Resilient

Demented

Number of subjects, total N = 55

8

20

27

Mini-mental state exam

Mean (SD)

29 (0.8)

29.1 (0.9)

23.7 (6.6)

Age (years)

Mean (SD)

82.6 (8.3)

88.9 (9)

88.1 (6.1)

Gender

Female N (%)

4 (50%)

11 (55%)

13 (48%)

Male N (%)

4 (50%)

9 (45%)

14 (52%)

ApoE allele status

ApoE2 allele (%)

0 (0%)

2 (9%)

2 (7%)

ApoE3 allele (%)

8 (100%)

18 (82%)

22 (79%)

ApoE4 allele (%)

0 (0%)

2 (9%)

4 (14%)

Neuropathology ('ABC' score)

A-Thal phase, range (mean)

A0-4 (1)

A0-4 (2.2)

A0-5 (2.2)

B-Braak stage, range (mean)

0-II (1.4)

III-IV (3.5)

III-IV (3.5)

C-CERAD score, range (mean)

C0-2 (0.4)

C0-3 (1.4)

C0-3 (1.2)

Vascular score

Composite score, mean (SD)*

3.8 (2)

3 (1.9)

5 (2.4)

PMI (hours)

Mean (SD)

24.5 (22.8)**

19.8 (11.8)

17.7 (9.4)**

  1. * Thal phase: No amyloid deposition (A0), amyloid in neocortex (A1), amyloid in allocortex/limbic region (A2), amyloid in diencephalon/basal ganglia (A3), amyloid in brainstem/midbrain (A4), amyloid in cerebellum (A5); ** CERAD score: No neuritic plaques (C0), sparse plaques (C1), moderate plaques (C2), frequent plaques (C3); *** Cerebrovascular composite score includes subscores for: hypertensive cerebrovascular, atherosclerosis, cerebral atherosclerosis, occlusive atherosclerosis and cerebral amyloid score. PMI Postmortem interval; SD Standard deviation