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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages

Fig. 9

Density of homeostatic microglia (TMEM119 + , P2RY12 +) in temporal and occipital white matter (WM) was significantly decreased in demented but not in resilient when compared to control brains (a). Representative photomicrographs of TMEM119 + and P2RY12 + microglia on sections from control, resilient and demented cases containing temporal WM are displayed on the right (b). C Control (Braak 0-II); R Resilient (Braak III/IV); D Demented (Braak III/IV); *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Scale bar 50 μm

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