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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages

Fig. 8

Density of reactive microglia (CD68+ , HLA-DR +) in temporal and occipital white matter (WM) was significantly increased in demented but not in resilient when compared to control brains (a). Representative photomicrographs of CD68+ and HLA-DR+ microglia on sections from control, resilient and demented cases containing temporal WM are displayed on the right (b). C Control (Braak 0-II); R Resilient (Braak III/IV); D Demented (Braak III/IV); **p < 0.01; ****p < 0.0001. Scale bar 50 μm

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