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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages

Fig. 6

Homeostatic microglia stained with TMEM119 and P2RY12 antibodies in temporal pole and visual cortex was significantly decreased in the temporal pole and visual cortex of demented but not in resilient when compared to control brains (a). Representative photomicrographs of TMEM119 + and P2RY12 + microglia on sections from control, resilient and demented cases containing visual cortex are displayed on the right (b). C Control (Braak 0-II); R Resilient (Braak III/IV); D Demented (Braak III/IV); *p < 0.05; **p < 0.01; ****p < 0.0001. Scale bars 50 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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