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Table 3 Study 2—Electron microscopy analysis of fiber morphometry (Fig. 5). Two -way ANOVA results with Holm-Sidak post hoc test and Cohen’s d effect size

From: Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury

Outcome measure F (DFn, DFd); p-value Adjusted p-value Cohen’s d effect size
Axon diameter Interaction:
F1,28 = 0.1513, p = 0.7002
Injury:
F1,28 = 11.08, p = 0.0025
Drug:
F1,28 = 0.01632, p = 0.8993
sham veh vs TBI veh:
ns, p = 0.1343
sham 4-AP vs TBI 4-AP:
ns, p = 0.0798
TBI veh vs TBI 4-AP:
ns, p = 0.9287
sham veh vs TBI veh:
d = 0.959
sham 4-AP vs TBI 4-AP:
d = 1.380
TBI veh vs TBI 4-AP:
d = 0.115
Myelin thickness Interaction:
F1,28 = 1.159, p = 0.2908
Injury:
F1,28 = 106.7, p < 0.0001
Drug:
F1,28 = 0.09095, p = 0.7652
sham veh vs TBI veh:
p < 0.0001
sham 4-AP vs TBI 4-AP:
p < 0.0001
TBI veh vs TBI 4-AP:
ns, p = 0.5189
sham veh vs TBI veh:
d = 3.081
sham 4-AP vs TBI 4-AP:
d = 4.219
TBI veh vs TBI 4-AP:
d = 0.563
  1. veh saline vehicle control; ns: non-significant (p > 0.05). Sham veh vs sham 4-AP ns for each measure (p > 0.6 or higher)