Table 3 Study 2—Electron microscopy analysis of fiber morphometry (Fig. 5). Two -way ANOVA results with Holm-Sidak post hoc test and Cohen’s d effect size

Axon diameter

Interaction:

F_1,28 = 0.1513, p = 0.7002

Injury:

F_1,28 = 11.08, p = 0.0025

Drug:

F_1,28 = 0.01632, p = 0.8993

sham veh vs TBI veh:

ns, p = 0.1343

sham 4-AP vs TBI 4-AP:

ns, p = 0.0798

TBI veh vs TBI 4-AP:

ns, p = 0.9287

sham veh vs TBI veh:

d = 0.959

sham 4-AP vs TBI 4-AP:

d = 1.380

TBI veh vs TBI 4-AP:

d = 0.115

Myelin thickness

Interaction:

F_1,28 = 1.159, p = 0.2908

Injury:

F_1,28 = 106.7, p < 0.0001

Drug:

F_1,28 = 0.09095, p = 0.7652

sham veh vs TBI veh:

p < 0.0001

sham 4-AP vs TBI 4-AP:

p < 0.0001

TBI veh vs TBI 4-AP:

ns, p = 0.5189

sham veh vs TBI veh:

d = 3.081

sham 4-AP vs TBI 4-AP:

d = 4.219

TBI veh vs TBI 4-AP:

d = 0.563