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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: The distribution and density of Huntingtin inclusions across the Huntington disease neocortex: regional correlations with Huntingtin repeat expansion independent of pathologic grade

Fig. 5

ad: Selected examples of brains that ranged from grade 1 to grade 4. ad High power image of the dorsal head of the caudate nucleus. Arrows indicate neurons and demonstrate increasing neuronal loss with higher grades and worsening gliosis in higher grades. eh HTT/p62 immunostains demonstrate similar inclusion densities between the prefrontal neocortices (BA9) despite increasing grade. il Violin plots showing that HTT inclusion density is stable across neocortical regions, except between grades 2 and 4 in BA7. Horizontal dashed lines indicate the median. mn Bivariate regression plots demonstrate correlations between CAP score and HTT inclusion density in BA17, BA7 and BA9 (m, n = 65), however, no correlations were found between the clinical disease duration and HTT inclusion densities (n) across BA17, BA7, BA4 and BA9 (n = 22). Scale bar: 50 µm

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