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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Longitudinal dynamics of microvascular recovery after acquired cortical injury

Fig. 3

Microvascular regrowth in the aspiration cortical injury model does not follow the exact pattern as observed in the TBI model. A Longitudinal tracking of cortical micro-vessels from the same mouse spanning 6 to 62 dpi acquired from the identical field of view illustrates the progressive increase in vessel density after focal aspiration injury. Vessel center lines delineated by software, assist visualization (red lines). B The overall vessel density over the time course up to ~ 60 dpi in the aspiration injury model (n = 4). Control/sham (n = 4) mice have a stable vessel coverage up to ~ 30 dpi (gray line = linear regression with 95%CI fitted to 60 dpi). C The pattern of the number of junctions approximately mimics that of the vessel density in B. Control/sham mice have a stable number of vascular junctions over 30 dpi (gray line = linear regression with 95%CI fitted to 60 dpi n = 4;). D Similar to the TBI model, there is a strong linear correlation (R2 = 0.936, red line) where the number of junctions increases linearly with the increasing total vessel length (n = 4). The 95% confidence intervals are also plotted (red dashed line)

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