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Table 4 Morphometry of NMJs from confocal microscopic images

From: Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease

Morphological variable non-MND n = 5 mean ± SD MND n = 3 Mean ± SD P value un-paired t test
Primary Motor axon thickness (μm) 1.546 ± 0.5 1.257 ± 0.7 n. s. P = 0.44
Motor axon terminal sprout thickness (μm) 0.926 ± 0.4 0.73 ± 0.4 n.s. P = 0.49
Motor Nerve terminal Bouton size (μm2) 8.03 ± 1.7 5.01 ± 0.8 * P = 0.034
Total NT area (μm2) 74.33 ± 10.3 36.71 ± 12.2 ** P = 0.0033
AChR cluster patch size (μm2) 13.82 ± 2.2 18.82 ± 7.9 n.s. P = 0.36
Total AChR area (μm2) 126.5 ± 17.9 138.0 ± 26.9 n.s. P = 0.44
% of Motor nerve terminal to AChR overlap 60.14% ± 2.3 29.47% ± 7.1 *** P = 0.0001
  1. *, **, *** Unpaired t – test; n.s. = not significant