Skip to main content

Table 2 Muscle punch biopsies subjected to pathological analyses, and for generation of muscle satellite cells for in vitro studies

From: Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease

Donor IDs Sex Age Diagnosis Mutation (if known) Site of onset ALSFRS-R (at biopsy) No NMJs Interval—Symptom Onset to Biopsy
Con-1 F 54      2$, 7*  
Con-2 M 54      12$, 2*  
Con-6 F 65       
Con-7 M 65       
Con-8 M 47       
Con-9 M 61       
Con-10 M 71       
Con-11 F 65       
Con-12 M 70       
Con-13 M 44       
Con-14 M 57       
Con-15 M 32       
Con-16 M 64       
MND-2 M 47 Sporadic   Spinal 42 13$ 7.8
MND-8 M 65 Sporadic   Spinal 25   2.9
MND-9 M 51 Familial SOD1 Spinal 40   6.2
MND-10 M 47 Familial C9orf72 Spinal 41   10.2
MND-11 M 49 Sporadic   Spinal 40   5.5
MND-12 M 54 Sporadic   Spinal 33   57.0
MND-13 M 53 Sporadic   Spinal 33   20.4
MND-14 F 58 Sporadic   Spinal 35   33.5
MND-15 M 79 Sporadic   Spinal 28   57.1
MND-16 M 46 Familial C9orf72 Bulbar/Spinal 41   15.9
  1. Con = healthy donor control (Non-MND); ALSFRS-R—ALS Functional Rating Scale Revised; $Indicates NMJs found in intact muscle fiber samples; *Indicates NMJs found in cryosections