Table 2 Muscle punch biopsies subjected to pathological analyses, and for generation of muscle satellite cells for in vitro studies
From: Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease
| Donor IDs | Sex | Age | Diagnosis | Mutation (if known) | Site of onset | ALSFRS-R (at biopsy) | No NMJs | Interval—Symptom Onset to Biopsy |
|---|---|---|---|---|---|---|---|---|
| Con-1 | F | 54 | 2$, 7* | |||||
| Con-2 | M | 54 | 12$, 2* | |||||
| Con-6 | F | 65 | ||||||
| Con-7 | M | 65 | ||||||
| Con-8 | M | 47 | ||||||
| Con-9 | M | 61 | ||||||
| Con-10 | M | 71 | ||||||
| Con-11 | F | 65 | ||||||
| Con-12 | M | 70 | ||||||
| Con-13 | M | 44 | ||||||
| Con-14 | M | 57 | ||||||
| Con-15 | M | 32 | ||||||
| Con-16 | M | 64 | ||||||
| MND-2 | M | 47 | Sporadic | Spinal | 42 | 13$ | 7.8 | |
| MND-8 | M | 65 | Sporadic | Spinal | 25 | 2.9 | ||
| MND-9 | M | 51 | Familial | SOD1 | Spinal | 40 | 6.2 | |
| MND-10 | M | 47 | Familial | C9orf72 | Spinal | 41 | 10.2 | |
| MND-11 | M | 49 | Sporadic | Spinal | 40 | 5.5 | ||
| MND-12 | M | 54 | Sporadic | Spinal | 33 | 57.0 | ||
| MND-13 | M | 53 | Sporadic | Spinal | 33 | 20.4 | ||
| MND-14 | F | 58 | Sporadic | Spinal | 35 | 33.5 | ||
| MND-15 | M | 79 | Sporadic | Spinal | 28 | 57.1 | ||
| MND-16 | M | 46 | Familial | C9orf72 | Bulbar/Spinal | 41 | 15.9 |