Fig. 1
From: Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease
Muscle fiber type grouping occurs in MND patients. Sample cross sections of muscle from non-MND (Con-3 and -5) and from MND patients (MND-3 and -5). Sections were stained with H&E or combination anti-fast plus anti-slow myosin staining (brown stain and red stain respectively). Sections from MND-3 and -5 muscles reveal more grouping of slow myosin fibers (type I fibers;* red stained fibers in 2nd and 4th panels of second row) compared to those from Con-3 and -5, top row. Examples of atrophied (small) muscle fibers can also be seen in the MND sections (arrows). Scale bars = 50 μm