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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Impact of APOE genotype on prion-type propagation of tauopathy

Fig. 4

Induction of gliosis in K18-tau seeded PS19 mice homozygous for APOE. K18-tau fibrils were injected into the left hippocampus of 2.5-month-old mice and aged for 5 months. 7.5-month-old mice were analyzed for Iba-1 immunoreactive microgliosis (a, b) and GFAP-immunoreactive astrogliosis (c, d). Representative images from the hippocampus and cortex of K18-tau aggregate injected hemisphere (ipsilateral, ‘IPSI’) and uninjected hemisphere (contralateral, ‘CONTRA’) are shown (a, c). Quantification of the Iba-1 and GFAP immunostaining in 7.5-month-old mice is presented as % immunoreactivity in the cortex (Ctx) or hippocampus (Hpc) (b, d). Boxes in whole brain panel indicate selected areas used for high power zoomed panels. n = 9–12 mice/group. 1-way ANOVA *p < 0.05, **p < 0.01, ***p < 0.001. Scale bar: 3 mm (whole brain); 100 µm (hpc and ctx)

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