Table 2 Histological characteristics of BMD patients and controls
From: Muscle histological changes in a large cohort of patients affected with Becker muscular dystrophy
Study participants | |||
|---|---|---|---|
BMD (n = 45) | Controls (n = 15) | Adjusted P value a | |
CSA I (µm2) Fibre size | 4074 (2852–5833) | 3991 (3387–4695) | 1 |
CSA I Fibre size variability | 3316 (2246–4799) | 1200 (814–1463) | 0.0001 |
CSA II (µm2) Fibre size | 4680 (2649–5978) | 4681 (3333–5604) | 1 |
CSA II Fibre size variability | 4511 (3733–6506) | 1623 (1241–2231) | 0.0001 |
Nuclear Centralizations % | 4.5 (3–5) | 1 (0–1.5) | 0.0001 |
Regenerating fibres % | 3.4 (0–6.82) | 0 (0–0) | 0.0001 |
MFA % | 76.84 (62.68–83.10) | 90.85 (88.91–92.01) | 0.0001 |
Fatty tissue % | 0 (0–0) | 0 (0–0) | 0.0001 |
Range | 0–16.52 | 0–0.001 | |
Fibrotic tissue % | 22.45 (15.89–34.70) | 9.15 (7.72–10.76) | 0.0001 |
Other tissue % | 0 (0–0) | 0 (0–0) | 0.39 |
Range | 0–3.3 | 0–0.24 | |
Splitting fibres % | 3.1 (1.03–5.74) | 0 (0–0) | 0.0001 |
Necrosis fibres % | 0.79 (0–1.54) | 0 (0–0) | 0.0052 |