Fig. 6
From: Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment
Bdnf levels do not correlate with TrkB and Igf-1r activation. a Bdnf protein levels determined by ELISA in the developing and aging hippocampus, anterior and posterior cortex of wild-type mice. Data represent mean ± SD, One-way ANOVA, Tukey’s post hoc test; *p < 0.05, **p < 0.01, ***p < 0.001. b–e TrkB and Igf-1r immunoprecipitation from hippocampal and cortical lysates of 1 week, 3–4 weeks, 3- and 18-month-old wild-type mice. Data represent mean ± SD, ANOVA, Kruskal–Wallis test, Dunn’s post hoc test; *p < 0.05; n = number of mice. Values were normalized to 3-week-old wild-type hippocampus (blue column), UBF unbound fraction, IP immunoprecipitation