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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment

Fig. 1

IGFBP5 accumulates in CA1 pyramidal neurons and around plaques in the hippocampus of Alzheimer cases (AD). a IGFBP5-IR in the hippocampus of control case 2 and AD cases 11 (Braak IV) and 16 (Braak VI) visualized by DAB immunohistochemistry. b IGFBP5-IR visualized by DAB immunohistochemistry in granule cells of the dentate gyrus, neuronal cells of the hilus region, CA3 and CA1 hippocampal fields of control case 2 and AD cases 11 (Braak IV) and 16 (Braak VI). c Representative images of Aß42, AT8, IGFBP5 and IgG control DAB immunostaining in the hippocampus and prefrontal cortex of control case 2 and AD case 16. CA, cornu ammonis; DG, dentate gyrus. Scale bars a = 200 µm; b = 50 µm; c = 50 µm

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