Zika virus vertical transmission in interferon receptor1-antagonized Rag1−/− mice results in postnatal brain abnormalities and clinical disease

Table 2 Scoring of CNS pathology in P14 naïve, IgR and AIR^low mice

Pup ID	Treatment	Brain Neuronal degeneration, cell death	Spinal cord Neuronal degeneration, cell death	Spinal cord axonal degeneration
XZ395P1	naïve	0	0	0
XZ395P2	naïve	0	0	0
XZ395P3	naïve	0	0	0
XZ388P4	IgR	0	0	0
XZ388P5	IgR	0	0	0
XZ388P6	IgR	0	0	0
XZ388P7	IgR	0	0	0
XZ389P4	IgR	0	0	0
XZ389P5	IgR	0	0	0
XZ389P6	IgR	0	0	0
XZ389P7	IgR	0	0	0
XZ390P4	IgR	0	0	0
XZ390P5	IgR	0	0	0
XZ392P1	AIR^low	3	2	2
XZ393P1	AIR^low	3	2	2
XZ393P2	AIR^low	1	2	2

Scoring of brain tissue pathology in P14 mice. H&E-stained tissue samples were evaluated in detail and the following scoring system was applied: 0 = no lesions; 1 (exceedingly rare lesions), 2 (rare, scattered lesions), 3 (moderate numbers of evenly dispersed lesions) or 4 (severe lesions)

ISSN: 2051-5960