Zika virus vertical transmission in interferon receptor1-antagonized Rag1−/− mice results in postnatal brain abnormalities and clinical disease

Table 1 Scoring of CNS pathology in P7 naïve, IgR and AIR^low mice

Pup ID	Treatment	Brain Neuronal degeneration, cell death	Spinal cord Neuronal degeneration, cell death	Spinal cord axonal degeneration
XZ394P1	naïve	0	0	0
XZ394P2	naïve	0	0	0
XZ394P3	naïve	0	0	0
XZ3601P5	IgR	0	0	0
XZ3601P6	IgR	0	0	0
XZ3601P7	IgR	0	0	0
XZ3611P4	IgR	0	0	0
XZ3611P5	IgR	0	0	0
XZ3611P6	IgR	0	0	0
XZ383P5	IgR	0	0	0
XZ383P6	IgR	0	0	0
XZ384P4	IgR	1	0	0
XZ384P5	IgR	2	0	1
XZ357P4	AIR^low	2	2	1
XZ357P5	AIR^low	2	2	1
XZ357P6	AIR^low	2	3 (ganglion)	1
XZ386P3	AIR^low	1	0	1
XZ387P2	AIR^low	2	1	2
XZ387P3	AIR^low	1	0	0

Scoring of brain tissue pathology in P7 mice. H&E-stained tissue samples were evaluated in detail and the following scoring system was applied: 0 = no lesions; 1 (exceedingly rare lesions), 2 (rare, scattered lesions), 3 (moderate numbers of evenly dispersed lesions) or 4 (severe lesions)

ISSN: 2051-5960