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Table 1 Scoring of CNS pathology in P7 naïve, IgR and AIRlow mice

From: Zika virus vertical transmission in interferon receptor1-antagonized Rag1−/− mice results in postnatal brain abnormalities and clinical disease

Pup ID Treatment Brain Neuronal degeneration, cell death Spinal cord Neuronal degeneration, cell death Spinal cord axonal degeneration
XZ394P1 naïve 0 0 0
XZ394P2 naïve 0 0 0
XZ394P3 naïve 0 0 0
XZ3601P5 IgR 0 0 0
XZ3601P6 IgR 0 0 0
XZ3601P7 IgR 0 0 0
XZ3611P4 IgR 0 0 0
XZ3611P5 IgR 0 0 0
XZ3611P6 IgR 0 0 0
XZ383P5 IgR 0 0 0
XZ383P6 IgR 0 0 0
XZ384P4 IgR 1 0 0
XZ384P5 IgR 2 0 1
XZ357P4 AIRlow 2 2 1
XZ357P5 AIRlow 2 2 1
XZ357P6 AIRlow 2 3 (ganglion) 1
XZ386P3 AIRlow 1 0 1
XZ387P2 AIRlow 2 1 2
XZ387P3 AIRlow 1 0 0
  1. Scoring of brain tissue pathology in P7 mice. H&E-stained tissue samples were evaluated in detail and the following scoring system was applied: 0 = no lesions; 1 (exceedingly rare lesions), 2 (rare, scattered lesions), 3 (moderate numbers of evenly dispersed lesions) or 4 (severe lesions)