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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Zika virus vertical transmission in interferon receptor1-antagonized Rag1−/− mice results in postnatal brain abnormalities and clinical disease

Fig. 3

ZIKV infection in the CNS of P7 AIRlow neonates results in CNS structural abnormalities. H&E-stained whole brain sections from a IgR and b AIRlow mice are shown as representative examples of morphometric measurements taken of cortical thickness (red line in a, b) and cerebellar area (red polygon in a, b). Actual recorded values for each section are shown. The scale bar in (b) applies to (a). Morphometric measurements from each hemisphere of 3 naïve, 10 IgR and 6 AIRlow are shown for (c) cerebellar area and (d) cortical thickness. Each symbol represents the mean measurement from all sections for each hemisphere of each animal. The mean of the individually plotted data points for each group is represented by the horizontal black bars. A One-way ANOVA was used to compare cerebellar area (c, F2, 33 = 16.62, p < 0.0001) and cortical thickness (d, F2, 33 = 5.54, p = 0.0084) from samples from each group and a Tukey Multiple Comparisons Test was used to determine significance between groups. *p < 0.05, ***p < 0.001, ****p < 0.0001 indicate significance between groups

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