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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Zika virus vertical transmission in interferon receptor1-antagonized Rag1−/− mice results in postnatal brain abnormalities and clinical disease

Fig. 1

Survival of AIR pups increases with decreasing amounts of virus and anti-IFNAR antibody administered to the dam. a Neonates born to AIR, AIRlow and IgR treated, ZIKV infected pregnant mice (see Results section for different treatments) were followed for survival out to postnatal day 7 (P7) and the results are presented as Kaplan–Meier survival curves. Each curve indicates the survival of neonates from multiple dams treated with the indicated anti-IFNAR1/normal mouse IgG dose(s) and ZIKV infectious dose. The dash-dot line plotted on the Y-axis indicates median survival as determined by Kaplan–Meier. **p < 0.01, ****p < 0.0001 indicate a significant increase in survival based on a Log-rank Mantel-Cox curve comparison test. All survival curves were compared relative to the AIR (red) curve. Whole-head H&E-stained sections of an b IgR and c AIR treated neonate at P5 are shown. Notice the diminished brain volume in the (c, asterisks) AIR animal which corresponds to the only surviving AIR animal at P5 (a, red line termination). The tissue disruption in the brainstem and cerebellum of (b) is due to tissue processing and cutting artifact and is not associated with virus-induced pathology

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