Skip to main content

Table 1 Summary of charge transfer (NMDAQ/AMPAmax), N/A ratio, and NMDAR weighted decay time constant (τw)

From: Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ

Condition N NMDAQ/AMPAmax  ± SEM P value N/A ratio  ± SEM P value τ (w)  ± SEM P value
Electrical stimulation of Schaffer collateral/commissural projections
WT Con 17 0.135 0.006   0.62 0.02   134.7 2.75  
WT Ro 18 0.093 0.007 0.003 0.46 0.03 0.003 115.8 4.87 0.003
WT Aβ 46 0.100 0.005 0.003 0.49 0.02  < 0.001 124.4 2.72 0.013
Mapt−/− Con 33 0.140 0.008   0.62 0.03   142.5 5.22  
Mapt−/− Ro 48 0.106 0.010 0.032 0.53 0.04 0.108 121.0 4.51 0.037
Mapt−/− 40 0.132 0.008 0.368 0.58 0.03 0.292 135.5 5.53 0.292
Optical stimulation of left (L) or right (R) hippocampal CA3 projections
Mapt−/− L Con 8 0.183 0.027   0.74 0.08   146.1 16.56  
Mapt−/− L Ro 9 0.066 0.014 0.003 0.42 0.03 0.003 92.8 7.02 0.011
Mapt−/− R Con 11 0.116 0.016   0.62 0.05   116.1 8.84  
Mapt−/− R Ro 11 0.120 0.017 0.490 0.62 0.09 0.490 114.4 10.17 0.490
WT L Con 29 0.147 0.010   0.68 0.04   125.4 3.76  
WT L Aβ 31 0.116 0.010 0.032 0.54 0.04 0.018 123.8 5.75 0.490
WT R Con 31 0.169 0.012   0.77 0.06   134.5 3.64  
WT R Aβ 36 0.162 0.008 0.380 0.73 0.03 0.380 132.4 3.94 0.490
  1. P-values show Student’s t-test comparing control condition and drug condition following Benjamini-Hochberg correction. Significant P values (< 0.05) are indicated in bold