Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ

Table 1 Summary of charge transfer (NMDA_Q/AMPA_max), N/A ratio, and NMDAR weighted decay time constant (τ_w)

Condition	N	NMDA_Q/AMPA_max	± SEM	P value	N/A ratio	± SEM	P value	τ (w)	± SEM	P value
Electrical stimulation of Schaffer collateral/commissural projections
WT Con	17	0.135	0.006		0.62	0.02		134.7	2.75
WT Ro	18	0.093	0.007	0.003	0.46	0.03	0.003	115.8	4.87	0.003
WT Aβ	46	0.100	0.005	0.003	0.49	0.02	< 0.001	124.4	2.72	0.013
Mapt^−/− Con	33	0.140	0.008		0.62	0.03		142.5	5.22
Mapt^−/− Ro	48	0.106	0.010	0.032	0.53	0.04	0.108	121.0	4.51	0.037
Mapt^−/− Aβ	40	0.132	0.008	0.368	0.58	0.03	0.292	135.5	5.53	0.292
Optical stimulation of left (L) or right (R) hippocampal CA3 projections
Mapt^−/− L Con	8	0.183	0.027		0.74	0.08		146.1	16.56
Mapt^−/− L Ro	9	0.066	0.014	0.003	0.42	0.03	0.003	92.8	7.02	0.011
Mapt^−/− R Con	11	0.116	0.016		0.62	0.05		116.1	8.84
Mapt^−/− R Ro	11	0.120	0.017	0.490	0.62	0.09	0.490	114.4	10.17	0.490
WT L Con	29	0.147	0.010		0.68	0.04		125.4	3.76
WT L Aβ	31	0.116	0.010	0.032	0.54	0.04	0.018	123.8	5.75	0.490
WT R Con	31	0.169	0.012		0.77	0.06		134.5	3.64
WT R Aβ	36	0.162	0.008	0.380	0.73	0.03	0.380	132.4	3.94	0.490

P-values show Student’s t-test comparing control condition and drug condition following Benjamini-Hochberg correction. Significant P values (< 0.05) are indicated in bold

ISSN: 2051-5960