Fig. 3
From: Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ
Left/right difference of synaptic NMDARs in Mapt−/− recordings. a Diagram showing selective optical activation of ChR2-expressing hippocampal Schaffer collateral/commissural projections to CA1 pyramidal neurons originating in either the left or right CA3. b Representative traces for AMPAR/NMDAR-mediated currents (control condition: black, after GluN2B inhibitor Ro 25–6981: gray) in Mapt−/− mice expressing ChR2 in left or right CA3. c Cumulative distribution plots for charge transfer (NMDAQ/AMPAmax), N/A ratio, and weighted NMDAR current decay time constant (τw) in left or right injected Mapt−/− mice with and without Ro 25–6981. Statistical comparisons are presented in Table 1