Fig. 2
From: Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ
Human Aβ1-42 changes NMDAR contribution in wild-type but not Mapt−/− mice. NMDAR/AMPAR contribution to the EPSC at CA3-CA1 synapses following electrical stimulation under control conditions (black) and following incubation with Ro 25–6981 (gray) or Aβ (red). Representative traces for WT (Ai) and Mapt−/− (Bi) mice and cumulative distribution plots from wild-type (Aii) and Mapt−/− mice (Bii). Each point in the cumulative distribution plot shows average value per cell for: charge transfer (NMDAQ/AMPAmax), N/A ratio, and weighted NMDAR current decay time constant (τw). c Summary graph (NMDAQ/AMPAmax) to facilitate comparison between WT and Mapt−/− mice. Following two-way ANOVA (see text), significance was tested with post-hoc corrected Student’s t-tests to explore main effects, see also Table 1