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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer’s disease

Fig. 5

Reduction in endothelial glycocalyx in AD brain. AD tissue microarrays from the middle temporal gyrus (N = 21–37 per condition) were labelled for the total vessel marker collagen IV, and endothelial glycocalyx marker UEA1 lectin. a Representative images of lectin immunolabelling, and b quantification of lectin intensity in blood vessels in control and AD brains, segregated by vessel size. Scale = 250 μm. P-values represent results of an two-way ANOVA. Single nuclear RNA-seq from the human AD vasculature were obtained from https://twc-stanford.shinyapps.io/human_bbb/, and genes involved in c cell adhesion processes, and d fucosylation of the endothelial glycocalyx evaluated

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