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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Rare missense mutations in ABCA7 might increase Alzheimer’s disease risk by plasma membrane exclusion

Fig. 5

Subcellular localization of WT ABCA7 and mutant ABCA7. Confocal microscopy images of HeLa cells transiently expressing WT or mutant ABCA7-EmGFP. Calreticulin (magenta) was used as a marker for the ER. WT ABCA7 is present inside the ER as well as outside the ER, whereas the expression of mutant ABCA7 is predominantly seen in the ER, as shown by the near perfect colocalization between EmGFP and calreticulin. Scale bars represent 20 µm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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