Skip to main content
Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Rare missense mutations in ABCA7 might increase Alzheimer’s disease risk by plasma membrane exclusion

Fig. 3

Subcellular localization of WT ABCA7 and mutant ABCA7. Confocal microscopy images of HeLa cells transiently expressing WT or mutant ABCA7-EmGFP. Cells were labelled with WGA (magenta) as a plasma membrane marker. WT ABCA7 locates to the plasma membrane and intracellularly, whereas for the mutants the colocalization with WGA is lost. Instead, the EmGFP signal is concentrated intracellularly and shows a reticulate pattern characteristic for the ER. Scale bars represent 20 µm

Back to article page