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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: AQP4 labels a subpopulation of white matter-dependent glial radial cells affected by pediatric hydrocephalus, and its expression increased in glial microvesicles released to the cerebrospinal fluid in obstructive hydrocephalus

Fig. 1

AQP4 immunoreactivity in the archicortex of control samples at 12 and 17 PCW a Panoramic image of a coronal brain section, 13 PCW. b Magnification of the square in A, indicating selective expression of AQP4 in dorsal hippocampus, mostly in the VZ and PM zones. c Magnification of the square in b, indicating that AQP4 is expressed in radial processes similar to those associated with radial glial cells (arrows) and in astrocyte cellular bodies (arrowhead). d Magnification of the area where the ventral hippocampus will develop. Arrow indicates that immunoreactivity is restricted to the VZ associated with the future archicortex. e Panoramic image of a coronal section of fetal brain at 17 PCW. Arrows indicate that expression is still associated with VZ and PM zones in the archicortex but has also expanded dorsally through degenerating dorsal hippocampus and ventrally toward the definitive hippocampus. f Magnification of the square on the dorsal hippocampus in E. Arrowhead indicates AQP4 expression in cellular bodies of degenerating dorsal hippocampus and arrow indicates radial processes. g, h Magnification of ventral hippocampus. Arrowheads indicate immunoreactivity of cell bodies. Arrows indicate expression in glial radial cell-like cells, with processes that progress toward the fornix, not radially. DHip, dorsal hippocampus; Fo, fornix; GE, ganglionic eminence; Htha, hypothalamus; LV, lateral ventricle; PCW, post-conceptional weeks; PM, pia mater; Tha, thalamus; VHip, ventral hippocampus; VZ, ventricular zone. Scale bars: a 500 µm; b 250 µm; c 30 µm; d 60 µm; e 600 µm; f, g 300 µm; h 75

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