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Table 3 Multivariable Cox regression models including age acceleration, GBM classification, global HM-entropy (HME) and HME at promoter CpGs

From: DNA methylation-based age acceleration observed in IDH wild-type glioblastoma is associated with better outcome—including in elderly patients

Model Variables EORTC/NCIC & LN-Pilot (N = 177) Nordic study (N = 105)
Modality HR z-value Pr( >|z|) Modality HR z-value Pr( >|z|)
Age acceleration [years]
  Treatment (TRT) TMZ + RT 1.34862 1.31435 0.18873 TMZ 1.06845 0.23966 0.81059
  MGMT MGMTmeth 0.77273 − 1.10615 0.26866 MGMTmeth 1.13894 0.50912 0.61067
  Age Acceleration   0.99124 − 2.46259 0.01379   0.98549 − 3.15493 0.00161
  TRT x MGMT TMZ + RT x MGMTmeth 0.27215 − 3.94628 0.00008 TMZ x MGMTmeth 0.47267 − 1.66716 0.09548
GBM classification
  Treatment (TRT) TMZ + RT 1.19859 0.80597 0.42026 TMZ 1.12226 0.41692 0.67674
  MGMT MGMTmeth 0.70503 − 1.52048 0.12839 MGMTmeth 1.05817 0.22379 0.82292
  GBM classification GBM_RTK_I 1.54086 1.91764 0.05516 GBM_RTK_I 1.12308 0.41675 0.67686
   GBM_RTK_II 0.91674 − 0.48386 0.62848 GBM_RTK_II 0.52912 − 2.63579 0.00839
  TRT x MGMT TMZ + RT x MGMTmeth 0.31994 − 3.55697 0.00038 TMZ x MGMTmeth 0.53507 − 1.39736 0.16230
Global HME
  Treatment (TRT) TMZ + RT 1.12690 0.55400 0.57958 TMZ 1.08996 0.30807 0.75803
  MGMT MGMTmeth 0.69179 − 1.61442 0.10644 MGMTmeth 0.89983 − 0.42203 0.67300
  HME   3.18126 0.49623 0.61973   164.80788 1.64897 0.09915
   TMZ + RT x MGMTmeth 0.34584 − 3.38245 0.00072 TMZ x MGMTmeth 0.54313 − 1.36378 0.17264
HME promoter CpG
  Treatment (TRT) TMZ + RT 1.15106 0.65024 0.51554 TMZ 1.17499 0.58063 0.56149
  MGMT Methylated 0.73235 − 1.33193 0.18288 MGMTmeth 0.95937 − 0.16478 0.86912
  HME prom CpG   0.04405 − 1.14097 0.25388   0.16488 − 0.58312 0.55982
  TRT x MGMT TMZ + RT x MGMTmeth 0.33173 − 3.48833 0.00049 TMZ x MGMTmeth 0.53779 − 1.39207 0.16390
  1. Cox models, adjusted for Treatment (TRT), methylation status of MGMT promoter (MGMT), and the interaction of these two variables (TRT X MGMT)
  2. HME, human methylation entropy; HR, hazard ratio; MGMTmeth, methylated MGMT; Pr(( >|z|), p-value for z-statistics; P-value <0.5, bold