Table 1 Baseline description and parameters of GBM datasets
Datasets | DKFZ (%) | EORTC/NCIC & LN-Pilot (%) | Nordic (%) | TCGA (%) | P-Value |
|---|---|---|---|---|---|
N | 214 (100) | 177 (100) | 105 (100) | 99 (100) | |
Sex | 0.1994 | ||||
Female | 101 (47) | 66 (37) | 40 (38) | 42 (42) | |
Male | 113 (53) | 111 (63) | 65 (62) | 57 (58) | |
Patient age [years] | < 0.0001 | ||||
Min | 29 | 27 | 60 | 33 | |
Max | 86 | 70 | 83 | 85 | |
Mean, SD | 60.34 ± 11.25 | 54.35 ± 8.98 | 70.82 ± 4.66 | 61.95 ± 10.64 | |
DNAm age [years] | 0.0001 | ||||
Min | 40.02 | 39.56 | 57.90 | 30.11 | |
Max | 174.01 | 167.42 | 180.10 | 186.71 | |
Mean, SD | 94.65 ± 22.58 | 94.13 ± 26.13 | 107.75 ± 25.17 | 98.71 ± 27.72 | |
Age Acc [years] | 0.1737 | ||||
Min | − 13.45 | − 9.50 | − 7.19 | − 14.89 | |
Max | 135.01 | 104.14 | 108.49 | 120.71 | |
Mean (SD) | 34.31 ± 21.25 | 39.78 ± 24.71 | 36.93 ± 25.09 | 36.76 ± 26.67 | |
GBM subgroup | 0.0141 | ||||
GBM_MES | 48 (22) | 66 (37) | 43 (41) | 31 (31) | |
GBM_RTK_I | 51 (24) | 30 (17) | 20 (19) | 19 (19) | |
GBM_RTK_II | 115 (54) | 81 (46) | 42 (40) | 49 (49) | |
MGMT-STP27 | 0.4871 | ||||
U | 100 (47) | 91 (51) | 55 (52) | 55 (56) | |
M | 114 (53) | 86 (49) | 50 (48) | 44 (44) | |
MGMT score | 0.3412 | ||||
Min | − 5.58 | − 10.48 | − 4.09 | − 11.68 | |
Max | 6.98 | 7.35 | 8.16 | 6.34 | |
Mean, SD | 0.62 ± 3.59 | 0.22 ± 3.38 | 0.32 ± 3.31 | − 0.23 ± 3.85 | |
HM purity | 0.6177 | ||||
Min | 0.31 | 0.42 | 0.42 | 0.39 | |
Max | 0.99 | 0.95 | 0.98 | 0.98 | |
Mean, SD | 0.73 ± 0.14 | 0.74 ± 0.14 | 0.75 ± 0.14 | 0.75 ± 0.14 | |
Global HM entropy | 0.9938 | ||||
Min | 0.45 | 0.47 | 0.47 | 0.49 | |
Max | 0.64 | 0.64 | 0.62 | 0.63 | |
Mean, SD | 0.55 ± 0.03 | 0.55 ± 0.03 | 0.55 ± 0.03 | 0.55 ± 0.03 | |
HME Prom CpG: | 0.2526 | ||||
Min | 0.27 | 0.29 | 0.29 | 0.28 | |
Max | 0.48 | 0.47 | 0.45 | 0.41 | |
Mean, SD | 0.36 ± 0.03 | 0.36 ± 0.03 | 0.36 ± 0.03 | 0.36 ± 0.03 |