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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: DNA methylation-based age acceleration observed in IDH wild-type glioblastoma is associated with better outcome—including in elderly patients

Fig. 5

Heatmap of DNA methylation of functional CpGs in DDR genes significantly associated with DNAm age acceleration. The clustering was obtained by Ward’s algorithm using Euclidean distance based on centered and scaled data. The samples and the methylation of the functional CpGs associated with DDR genes were classified into 3 clusters (consensus k‑means clustering for 200 repetitions) and 5 clusters (consensus k‑means clustering for 200 repetitions), respectively. The samples are annotated with the patients’ age (age in years), DNAm age acceleration (Accel, in years), MGMT methylation score (MGMTscore), Purity index based on DNA methylation (HMpurity), study origin (study) and GBM classification (Class). The probes are annotated for statistical significance associated with age (Age), DNAm age acceleration (Accel) and GBM classification (Class); yes, red; no, blue. The Spearman’s correlation of methylation with expression (measure of functionality) is given for each CpG, Corr (E/M). The clustering is dominated by the high correlation of DNA methylation among the functional CpGs of individual genes

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