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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia

Fig. 8

Treatment with LXR-receptor agonists improves axonal organisation in Arl6IP1 KO models of SGP61. a Representative confocal images of the smooth ER marker Rtnl1::YFP (green) within posterior NMJs (DLG, magenta) from treated CRISPR Control and Arl6IP1 KO larvae. b Graph represents mean ± SEM proportion of continuous Rtnl1::YFP staining identified in larval axons. n = 19–21 animals. Statistics consist of two-way ANOVA with Bonferroni’s multiple comparisons test. c Representative confocal images of mitochondria (green) within posterior axon bundles from treated CRISPR control and Arl6IP1 KO larvae. Graphs represent mean ± SEM mitochondrial circularity d and size e within axon in CRISPR Control and Arl6IP1 KO. n = 18–24 animals. Statistics consist of two-way ANOVA with Tukey’s multiple comparisons test

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