Fig. 8From: Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegiaTreatment with LXR-receptor agonists improves axonal organisation in Arl6IP1 KO models of SGP61. a Representative confocal images of the smooth ER marker Rtnl1::YFP (green) within posterior NMJs (DLG, magenta) from treated CRISPR Control and Arl6IP1 KO larvae. b Graph represents mean ± SEM proportion of continuous Rtnl1::YFP staining identified in larval axons. n = 19–21 animals. Statistics consist of two-way ANOVA with Bonferroni’s multiple comparisons test. c Representative confocal images of mitochondria (green) within posterior axon bundles from treated CRISPR control and Arl6IP1 KO larvae. Graphs represent mean ± SEM mitochondrial circularity d and size e within axon in CRISPR Control and Arl6IP1 KO. n = 18–24 animals. Statistics consist of two-way ANOVA with Tukey’s multiple comparisons testBack to article page