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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia

Fig. 5

Endogenously tagged ARL6IP1 binds to ER-shaping proteins and localises to the tubular ER. a 3xFLAG-tagged ARL6IP1 expression was verified by western blot. b ARL6IP1-FLAG (red) exhibits an ER localisation pattern similar to that of untagged ARL6IP1 with strong colocalisation with the tubular ER marker, RTN4 (green). c Representative confocal images showing strong colocalisation between endogenously tagged ARL6IP1 and RTN3 (left) or REEP5 (right). d Western blot analysis of FLAG M2 affinity co-immunoprecipitated reveals interaction of ARL6IP1-FLAG with RTN3 and REEP5

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Acta Neuropathologica Communications

ISSN: 2051-5960

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