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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies

Fig. 6

Microglial morphological features and clusters correlate with pTau, Aβ, and pSyn burdens in the hippocampus and follow a subregional pattern. Correlation plots between pathologies and microglial morphological features (ac) and morphological clusters (df) in CA1, CA3 and DG/CA4 in CTL, AD and DLB conditions. A list and description of all morphological features with prototypic morphologies for lowest and highest value can be found in Additional file 1: Fig. S3 online resource). ac Various microglia morphological changes are correlated to one or two AD and DLB pathologies in a subregion-dependent manner. df In a subfield-dependent manner, disease-enriched clusters 3 and 5 are positively correlated with one or two pathologies whereas disease-depleted cluster 7 present negative correlations. Statistically significant values (Spearman’s correlation) are indicated by a dot, the colour gives an estimation of the correlation (positive correlations in blue, negative correlations in red). Black crosses indicate unsignificant correlations

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