Skip to main content
Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies

Fig. 3

Microglia morphological cluster distribution varies according to the disease and the hippocampal subfield. Ward hierarchical clustering on the matrix of 32,447 microglia based on 16 features defines seven distinct morphological clusters. a Hierarchical clustering dendrogram. b Projection on a UMAP of the seven clusters where each of 32,447 individual microglia is represented by a dot. c Scaled prototypical morphologies of microglia associated to the seven clusters inside the UMAP. d, e Histograms showing the variation in abundance (average composition in %) of the seven clusters according to the condition (d) and across subfield per condition (e). Overall, clusters 3 and 5 are enriched in the disease conditions, whereas cluster 7 is depleted. Scale bar in c = 30 µm. Wilcoxon–Mann–Whitney U-test P values are indicated in the graphs: *P < 0.05; **P < 0.01 and ***P < 0.001

Back to article page

Acta Neuropathologica Communications

ISSN: 2051-5960

Contact us