Table 2 Clinical and molecular features in test cohort IDH-mutant CIN and CS astrocytomas by grade

Lower-Grade (2–3)

Cluster 1 (CIN)

41

19:22

43.3 ± 2.1

22.0 ± 2.4

32:9

50.8

Cluster 2 (CS)

167

97:70

36.9 ± 1.3

7.8 ± 1.8

144:39

114

p-value

–

0.2194

0.0245

0.0003

0.9281

 < 0.0001

Grade 2

Cluster 1 (CIN)

15

5:10

46.8 ± 3.7

17.0 ± 2.2

8:7

62.9

Cluster 2 (CS)

95

54:41

36.2 ± 2.9

7.0 ± 0.5

82:29

122.4

p-value

–

0.1028

0.1585

 < 0.0001

0.1279

0.0093

Grade 3

Cluster 1 (CIN)

26

14:12

41.9 ± 2.5

24.1 ± 3.3

24:2

47.9

Cluster 2 (CS)

72

43:29

37.9 ± 1.4

8.7 ± 0.8

62:10

93.1

p-value

–

0.6474

0.1521

 < 0.0001

0.5073

0.0243

Grade 4

Cluster 1 (CIN)

16

7:9

38.7 ± 1.9

19.4 ± 2.5

14:2

36.8

Cluster 2 (CS)

21

13:8

40.9 ± 1.6

14.0 ± 1.3

18:3

36.3

p-value

–

0.3309

0.3795

0.0481

0.8749

0.8508