Table 1 Clinical and molecular features in IDH-mutant CIN and CS astrocytomas
From: Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas
Cluster | n | Gender (M:F) | Age (years) | WHO Grade | CNV (%) | CIN70 mRNA expression (High:Low) | MGMT promoter methylation status | Median PFS (months) | Median OS (months) | |
|---|---|---|---|---|---|---|---|---|---|---|
2016 (2:3:4) | 2021 (2:3:4) | |||||||||
Reference cohort | ||||||||||
Cluster 1 (CIN) | 11 | 4:7 | 38.4 ± 2.9 | 2:8:1 | 1:6:4 | 20.2 ± 5.8 | 11:0 | 7:4 | 31.1 | 36.8 |
Cluster 2 (CS) | 31 | 19:12 | 39.0 ± 1.9 | 21:10:0 | 17:9:5 | 7.0 ± 1.0 | 3:27 | 10:20 | 95.1 | 122.4 |
p-value | – | 0.1795 | 0.7779 | 0.0037 | 0.0224 | 0.0018 |  < 0.0001 | 0.1509 | 0.0077 |  < 0.0001 |
Test cohort | ||||||||||
Cluster 1 (CIN) | 57 | 26:31 | 41.9 ± 1.6 | 17:36:4 | 15:26:16 | 21.2 ± 1.9 | 37:12 | 46:11 | 38.0 | 50.5 |
Cluster 2 (CS) | 188 | 110:78 | 37.4 ± 1.5 | 106:76:6 | 95:72:21 | 7.4 ± 0.5 | 16:167 | 162:26 | 62.0 | 98.2 |
p-value | – | 0.0956 | 0.0756 | 0.0010 | 0.0007 |  < 0.0001 |  < 0.0001 | 0.3000 | 0.0034 | 0.0002 |