Fig. 2
From: Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas
a–b Uniform manifold approximation and projection (UMAP) plotting demonstrating separate clustering between the test cohort WHO grade 2–4 IDH-mutant astrocytomas with chromosomal instability (CIN) and those with chromosomal stability (CS). c Cluster analysis heatmap summarizing DNA methylation profiles of the test cohort (n = 245). d Cases in cluster 1 (CIN) demonstrated significantly higher overall copy number variation on initial resection compared to cases in cluster 2 (CS)